ABCG2 null alleles define the Jr(a-) blood group phenotype.
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Zelinski T, Coghlan G, Liu XQ, Reid ME
ABCG2 null alleles define the Jr(a-) blood group phenotype.
Nat Genet. 2012 Jan 15;44(2):131-2. doi: 10.1038/ng.1075.
- PubMed ID
- 22246507 [ View in PubMed]
- Abstract
The high-incidence erythrocyte blood group antigen Jr(a) has been known in transfusion medicine for over 40 years. To identify the gene encoding Jr(a), we performed SNP analysis of genomic DNA from six Jr(a-) individuals. All individuals shared a homozygous region of 397,000 bp at chromosome 4q22.1 that contained the gene ABCG2, and DNA sequence analysis showed that ABCG2 null alleles define the Jr(a-) phenotype.