Discovery of a novel class of 2-aminopyrimidines as CDK1 and CDK2 inhibitors.

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Citation

Lee J, Kim KH, Jeong S

Discovery of a novel class of 2-aminopyrimidines as CDK1 and CDK2 inhibitors.

Bioorg Med Chem Lett. 2011 Jul 15;21(14):4203-5. doi: 10.1016/j.bmcl.2011.05.081. Epub 2011 May 27.

PubMed ID
21684737 [ View in PubMed
]
Abstract

A series of new 2-(2-aminopyrimidin-4-yl)phenol derivatives were synthesized as potential antitumor compounds. Substitution with pyrrolidine-3,4-diol at the 4-position of phenol provided potent inhibitory activity against CDK1 and CDK2. X-ray crystal structural studies were performed to account for the effect of the substituent on both the enzymatic and cell growth inhibitory activities.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Cyclin-dependent kinase 2P24941Details