Discovery of a novel class of 2-aminopyrimidines as CDK1 and CDK2 inhibitors.
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Lee J, Kim KH, Jeong S
Discovery of a novel class of 2-aminopyrimidines as CDK1 and CDK2 inhibitors.
Bioorg Med Chem Lett. 2011 Jul 15;21(14):4203-5. doi: 10.1016/j.bmcl.2011.05.081. Epub 2011 May 27.
- PubMed ID
- 21684737 [ View in PubMed]
- Abstract
A series of new 2-(2-aminopyrimidin-4-yl)phenol derivatives were synthesized as potential antitumor compounds. Substitution with pyrrolidine-3,4-diol at the 4-position of phenol provided potent inhibitory activity against CDK1 and CDK2. X-ray crystal structural studies were performed to account for the effect of the substituent on both the enzymatic and cell growth inhibitory activities.