Crystal structure of cyclin-dependent kinase 2.

Article Details

Citation

De Bondt HL, Rosenblatt J, Jancarik J, Jones HD, Morgan DO, Kim SH

Crystal structure of cyclin-dependent kinase 2.

Nature. 1993 Jun 17;363(6430):595-602.

PubMed ID
8510751 [ View in PubMed
]
Abstract

Cyclin-dependent kinase 2 (CDK2) is a member of a highly conserved family of protein kinases that regulate the eukaryotic cell cycle. The crystal structures of the human CDK2 apoenzyme and its Mg2+ ATP complex have been determined to 2.4 A resolution. The structure is bi-lobate, like that of the cyclic AMP-dependent protein kinase, but contains a unique helix-loop segment that interferes with ATP and protein substrate binding and probably plays a key part in the regulation of all cyclin-dependent kinases.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Cyclin-dependent kinase 2P24941Details