Crystal structure of cyclin-dependent kinase 2.
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De Bondt HL, Rosenblatt J, Jancarik J, Jones HD, Morgan DO, Kim SH
Crystal structure of cyclin-dependent kinase 2.
Nature. 1993 Jun 17;363(6430):595-602.
- PubMed ID
- 8510751 [ View in PubMed]
- Abstract
Cyclin-dependent kinase 2 (CDK2) is a member of a highly conserved family of protein kinases that regulate the eukaryotic cell cycle. The crystal structures of the human CDK2 apoenzyme and its Mg2+ ATP complex have been determined to 2.4 A resolution. The structure is bi-lobate, like that of the cyclic AMP-dependent protein kinase, but contains a unique helix-loop segment that interferes with ATP and protein substrate binding and probably plays a key part in the regulation of all cyclin-dependent kinases.