Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2.

Article Details

Citation

Lawrie AM, Noble ME, Tunnah P, Brown NR, Johnson LN, Endicott JA

Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2.

Nat Struct Biol. 1997 Oct;4(10):796-801.

PubMed ID
9334743 [ View in PubMed
]
Abstract

Staurosporine exhibits nanomolar IC50 values against a wide range of protein kinases. The structure of a CDK2 staurosporine complex explains the tight binding of this inhibitor, and suggests features to be exploited in the design of specific inhibitors of CDKs.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Cyclin-dependent kinase 2P24941Details