Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2.
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Lawrie AM, Noble ME, Tunnah P, Brown NR, Johnson LN, Endicott JA
Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2.
Nat Struct Biol. 1997 Oct;4(10):796-801.
- PubMed ID
- 9334743 [ View in PubMed]
- Abstract
Staurosporine exhibits nanomolar IC50 values against a wide range of protein kinases. The structure of a CDK2 staurosporine complex explains the tight binding of this inhibitor, and suggests features to be exploited in the design of specific inhibitors of CDKs.