Mechanism of activation of a human oncogene.
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Tabin CJ, Bradley SM, Bargmann CI, Weinberg RA, Papageorge AG, Scolnick EM, Dhar R, Lowy DR, Chang EH
Mechanism of activation of a human oncogene.
Nature. 1982 Nov 11;300(5888):143-9.
- PubMed ID
- 6290897 [ View in PubMed]
- Abstract
The oncogene of the human EJ bladder carcinoma cell lines arose via alteration of a cellular proto-oncogene. Experiments are presented that localize the genetic lesion that led to activation of the oncogene. The lesion has no affect on levels of expression of the oncogene. Instead, it affects the structure of the oncogene-encoded protein.