The DNA binding subunit of NF-kappa B is identical to factor KBF1 and homologous to the rel oncogene product.

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Citation

Kieran M, Blank V, Logeat F, Vandekerckhove J, Lottspeich F, Le Bail O, Urban MB, Kourilsky P, Baeuerle PA, Israel A

The DNA binding subunit of NF-kappa B is identical to factor KBF1 and homologous to the rel oncogene product.

Cell. 1990 Sep 7;62(5):1007-18.

PubMed ID
2203531 [ View in PubMed
]
Abstract

The major determinant in the transcriptional control of class I genes of the major histocompatibility complex is an enhancer sequence located around -170 from the transcription start site, which binds a factor named KBF1. We have isolated a complementary cDNA coding for KBF1 and identified the DNA binding and dimerization domain of the protein. Because KBF1 and the transcription factor NF-kappa B bind to similar sequences, we investigated the relationship between these two molecules. It appeared that KBF1 is, by all criteria used, identical to the 50 kd DNA binding subunit of NF-kappa B. KBF1 (and therefore p50) also displays extensive amino acid sequence homology with the v-rel oncogene and the Drosophila maternal morphogen dorsal. In vitro experiments suggest functional homologies between KBF1 and v-rel.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Nuclear factor NF-kappa-B p105 subunitP19838Details