Structure and chromosomal localization of the human lymphotoxin gene.

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Citation

Nedwin GE, Jarrett-Nedwin J, Smith DH, Naylor SL, Sakaguchi AY, Goeddel DV, Gray PW

Structure and chromosomal localization of the human lymphotoxin gene.

J Cell Biochem. 1985;29(3):171-81.

PubMed ID
3001109 [ View in PubMed
]
Abstract

We have isolated, sequenced, and determined the chromosomal localization of the gene encoding human lymphotoxin (LT). The single copy gene was isolated from a human genomic library using a 32P-labeled 116 bp synthetic DNA fragment whose sequence was based on the NH2-terminal amino acid sequence of LT. The gene spans 3 kb of DNA and is interrupted by three intervening sequences. The LT gene is located on human chromosome 6, as determined by Southern blot analysis of human-murine hybrid DNA. Putative transcriptional control regions and areas of homology with the promoters of interferon and other genes are identified.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Lymphotoxin-alphaP01374Details