Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity.
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Gray PW, Aggarwal BB, Benton CV, Bringman TS, Henzel WJ, Jarrett JA, Leung DW, Moffat B, Ng P, Svedersky LP, et al.
Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity.
Nature. 1984 Dec 20-1985 Jan 2;312(5996):721-4.
- PubMed ID
- 6334807 [ View in PubMed]
- Abstract
A chemically-synthesized gene and natural complementary DNA coding for human lymphotoxin were isolated and engineered for expression in Escherichia coli. Purified recombinant lymphotoxin shows cytotoxic activity on murine and human tumour cell lines in vitro and causes necrosis of certain murine sarcomas in vivo.