The Role of Neprilysin Inhibitors in Cardiovascular Disease.

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Mills J, Vardeny O

The Role of Neprilysin Inhibitors in Cardiovascular Disease.

Curr Heart Fail Rep. 2015 Dec;12(6):389-94. doi: 10.1007/s11897-015-0270-8.

PubMed ID

26466607 [ View in PubMed

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Abstract

Heart failure affects over five million Americans each year and contributes to morbidity, mortality, and high health care costs. Despite the benefits of RAAS and SNS blockers, 5-year survival rates in patients with heart failure remain low, necessitating continued research and new drug targets. LCZ696 (sacubitril/valsartan) is an angiotensin-receptor neprilysin inhibitor recently approved for HFrEF, with dual actions that result in enhancement of natriuretic peptide levels and blockade of angiotensin II activities. This drug shows promise in further improving clinical outcomes in HFrEF and is being studied in patients with HFpEF. In the PARADIGM-HF study, LCZ696 (sacubitril/valsartan) was shown to reduce the composite of cardiovascular mortality and heart failure hospitalizations compared with enalapril in patients with HFrEF taking guideline-directed medical therapies and resulted in prolonged survival. In trials, hypotension occurred more frequently with LCZ696 (sacubitril/valsartan) compared to an ACE inhibitor, warranting careful dose titration. Further clinical experience with LCZ696 (sacubitril/valsartan) will provide additional information on tolerability in a broad range of patients of various demographics.

DrugBank Data that Cites this Article

Drugs

Sacubitril

Drug Transporters

Drug	Transporter	Kind	Organism	Pharmacological Action	Actions
Sacubitril	Solute carrier organic anion transporter family member 1B1	Protein	Humans	Unknown	Inhibitor	Details
Sacubitril	Solute carrier organic anion transporter family member 1B3	Protein	Humans	Unknown	Inhibitor	Details