Different N-terminal forms of alpha 2-plasmin inhibitor in human plasma.
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Bangert K, Johnsen AH, Christensen U, Thorsen S
Different N-terminal forms of alpha 2-plasmin inhibitor in human plasma.
Biochem J. 1993 Apr 15;291 ( Pt 2):623-5.
- PubMed ID
- 8484741 [ View in PubMed]
- Abstract
Mature alpha 2-plasmin inhibitor in human plasma has 12 more N-terminal residues than hitherto anticipated. The first residue is the methionine at position 28, downstream from the N-terminus of the pre-protein. The cDNA sequence predicts that the site cleaved upon formation of the mature inhibitor is a typical signal-peptidase recognition site. The mature inhibitor (464 residues) and the previously reported, and presumably degraded, form with N-terminal asparagine (452 residues), are present in plasma in about equal amounts. They both form a stable complex with plasmin. Recent studies on a recombinant alpha 2-plasmin inhibitor suggest that the 12 additional residues have functional implications [Sumi, Ichikawa, Nakamura, Miura and Aoki (1989) J. Biochem. 106, 703-707].