Structure of the carboxyl-terminal half of human alpha 2-plasmin inhibitor deduced from that of cDNA.
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Sumi Y, Nakamura Y, Aoki N, Sakai M, Muramatsu M
Structure of the carboxyl-terminal half of human alpha 2-plasmin inhibitor deduced from that of cDNA.
J Biochem. 1986 Nov;100(5):1399-402.
- PubMed ID
- 3818581 [ View in PubMed]
- Abstract
A 1.7 kilobase cDNA clone isolated from a human liver cDNA library contained 822 nucleotides encoding the carboxyl-terminal 274 amino acid sequence of alpha 2-plasmin inhibitor, a stop codon and a 3' noncoding region of 0.9 kilobases. The amino acid sequence deduced from the cDNA shows 29-31% homology with those of other plasma protease inhibitors. The inhibitor's putative reactive-site peptide bond was Met-Ser, and the Met residue was located at the 91st position from the carboxyl-terminal end. The plasminogen binding site was located in the carboxyl-terminal region.