Complete nucleotide sequence of a human c-onc gene: deduced amino acid sequence of the human c-fos protein.
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van Straaten F, Muller R, Curran T, Van Beveren C, Verma IM
Complete nucleotide sequence of a human c-onc gene: deduced amino acid sequence of the human c-fos protein.
Proc Natl Acad Sci U S A. 1983 Jun;80(11):3183-7.
- PubMed ID
- 6574479 [ View in PubMed]
- Abstract
The complete nucleotide sequence of the c-fos(human) gene, the human cellular homolog of the oncogene (v-fos) of Finkel-Biskis-Jinkins murine osteosarcoma virus, has been determined. The c-fos(human) gene contains four discontinuous regions when compared with the v-fos gene. Three of the discontinuities are flanked by sequences characteristic of introns, while the fourth discontinuity is due to a deletion of 104 base pairs in the v-fos gene. As a consequence of the deletion, the predicted c-fos(human) and v-fos gene products differ at their carboxyl termini. Transcripts of 2.2 kilobases from the c-fos(human) gene have been identified in human cells. The sizes of these transcripts are in close agreement with the size expected from the nucleotide sequence after removal of introns.