Structure and function of the platelet integrin alphaIIbbeta3.
Article Details
- CitationCopy to clipboard
Bennett JS
Structure and function of the platelet integrin alphaIIbbeta3.
J Clin Invest. 2005 Dec;115(12):3363-9.
- PubMed ID
- 16322781 [ View in PubMed]
- Abstract
The platelet integrin alpha(IIb)beta(3) is required for platelet aggregation. Like other integrins, alpha(IIb)beta(3) resides on cell surfaces in an equilibrium between inactive and active conformations. Recent experiments suggest that the shift between these conformations involves a global reorganization of the alpha(IIb)beta(3) molecule and disruption of constraints imposed by the heteromeric association of the alpha(IIb) and beta(3) transmembrane and cytoplasmic domains. The biochemical, biophysical, and ultrastructural results that support this conclusion are discussed in this Review.