Anastellin, an FN3 fragment with fibronectin polymerization activity, resembles amyloid fibril precursors.

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Citation

Briknarova K, Akerman ME, Hoyt DW, Ruoslahti E, Ely KR

Anastellin, an FN3 fragment with fibronectin polymerization activity, resembles amyloid fibril precursors.

J Mol Biol. 2003 Sep 5;332(1):205-15.

PubMed ID
12946358 [ View in PubMed
]
Abstract

Anastellin is a carboxy-terminal fragment of the first FN3 domain from human fibronectin. It is capable of polymerizing fibronectin in vitro, and it displays anti-tumor, anti-metastatic and anti-angiogenic properties in vivo. We have determined the structure of anastellin using nuclear magnetic resonance spectroscopy and identified residues critical for its activity. Anastellin exhibits dynamic fluctuations and conformational exchange in solution. Its overall topology is very similar to the corresponding region of full-length FN3 domains. However, its hydrophobic core becomes solvent-accessible and some of its beta-strands lose their protection against hydrogen bonding to beta-strands from other molecules. These features seem to be relevant for the fibronectin polymerization activity of anastellin and resemble the characteristics of amyloid fibril precursors. We suggest that this analogy is not random and may reflect similarities between fibronectin and amyloid fibril formation.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
FibronectinP02751Details