Physicochemical properties of enrofloxacin.

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Citation

Lizondo M, Pons M, Gallardo M, Estelrich J

Physicochemical properties of enrofloxacin.

J Pharm Biomed Anal. 1997 Aug;15(12):1845-9.

PubMed ID
9278889 [ View in PubMed
]
Abstract

The physicochemical properties of enrofloxacin, a fluoroquinolone that inhibits the activity of bacterial DNA gyrase, are described. Its spectral, solubility and related physicochemical characteristics are discussed. The dissociation behaviour of enrofloxacin was examined by UV spectrophotometry at 25 degrees C in a series of buffers ranging from pH 1 to 10. The corresponding macro- and microscopic dissociation constants were calculated. The apparent n-octanol-water partition coefficients were measured from pH 2 to 10.

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