Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1.
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Navia MA, Fitzgerald PM, McKeever BM, Leu CT, Heimbach JC, Herber WK, Sigal IS, Darke PL, Springer JP
Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1.
Nature. 1989 Feb 16;337(6208):615-20.
- PubMed ID
- 2645523 [ View in PubMed]
- Abstract
The crystal structure of the protease of the human immunodeficiency virus type (HIV-1), which releases structural proteins and enzymes from viral polyprotein products, has been determined to 3 A resolution. Large regions of the protease dimer, including the active site, have structural homology to the family of microbial aspartyl proteases. The structure suggests a mechanism for the autoproteolytic release of protease and a role in the control of virus maturation.