The complete genome of the hyperthermophilic bacterium Aquifex aeolicus.
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Deckert G, Warren PV, Gaasterland T, Young WG, Lenox AL, Graham DE, Overbeek R, Snead MA, Keller M, Aujay M, Huber R, Feldman RA, Short JM, Olsen GJ, Swanson RV
The complete genome of the hyperthermophilic bacterium Aquifex aeolicus.
Nature. 1998 Mar 26;392(6674):353-8.
- PubMed ID
- 9537320 [ View in PubMed]
- Abstract
Aquifex aeolicus was one of the earliest diverging, and is one of the most thermophilic, bacteria known. It can grow on hydrogen, oxygen, carbon dioxide, and mineral salts. The complex metabolic machinery needed for A. aeolicus to function as a chemolithoautotroph (an organism which uses an inorganic carbon source for biosynthesis and an inorganic chemical energy source) is encoded within a genome that is only one-third the size of the E. coli genome. Metabolic flexibility seems to be reduced as a result of the limited genome size. The use of oxygen (albeit at very low concentrations) as an electron acceptor is allowed by the presence of a complex respiratory apparatus. Although this organism grows at 95 degrees C, the extreme thermal limit of the Bacteria, only a few specific indications of thermophily are apparent from the genome. Here we describe the complete genome sequence of 1,551,335 base pairs of this evolutionarily and physiologically interesting organism.
DrugBank Data that Cites this Article
- Polypeptides
Name UniProt ID 2-dehydro-3-deoxyphosphooctonate aldolase O66496 Details UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase O67648 Details 6,7-dimethyl-8-ribityllumazine synthase O66529 Details Transcription termination/antitermination protein NusG O67757 Details Uncharacterized protein aq_328 O66665 Details Transporter O67854 Details Sulfide-quinone reductase O67931 Details