Absorption and disposition of florfenicol after intravenous, intramuscular and subcutaneous dosing in alpacas.

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Pentecost RL, Niehaus AJ, Werle N, Lakritz J

Absorption and disposition of florfenicol after intravenous, intramuscular and subcutaneous dosing in alpacas.

Res Vet Sci. 2015 Apr;99:199-203. doi: 10.1016/j.rvsc.2015.02.006. Epub 2015 Feb 16.

PubMed ID
25744433 [ View in PubMed
]
Abstract

The objectives of this study were to define disposition and systemic availability of florfenicol in alpacas. Administration of 20 mg/kg doses to 8 male alpacas by i.v., i.m. and s.c. routes was performed by randomized, 3-way crossover design. Clearance and steady state volumes (Vdss) after i.v. injection were 5 ml/min/kg and 775 ml/kg respectively. Mean residence time (MRT) and terminal phase half-life (T1/2lambdaz) were 2.8 h and 2 h respectively. Maximum serum concentrations (Cmax) after i.m. were higher than s.c. administration (p = 0.034). After s.c. dosing, T1/2lambdaz and MRT were greater than after i.m. injection (p < 0.001; p = 0.006 respectively). Mean absorption time (MAT) after s.c. dosing was also prolonged (p = 0.006). Fractional absorption of florfenicol after i.m. and s.c. was not different (p > 0.05). Serum florfenicol concentrations remained >1.0 microg/ml for 20 h after i.m. dosing. Differences in rate and extent of florfenicol absorption after extravascular dosing could influence therapeutic outcomes.

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