The action of the insecticide imidacloprid on the respiratory rhythm of an insect: the beetle Tenebrio molitor.

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Zafeiridou G, Theophilidis G

The action of the insecticide imidacloprid on the respiratory rhythm of an insect: the beetle Tenebrio molitor.

Neurosci Lett. 2004 Jul 29;365(3):205-9.

PubMed ID
15246549 [ View in PubMed
]
Abstract

Imidacloprid is an insecticide which has the nicotinic acetylcholine receptors (nAChRs) as its primary site of action; acetylcholine is the major excitatory neurotransmitter in the insect central nervous system (CNS). In this study, the action of imidacloprid was tested using the synapses of the respiratory central pattern generator of the beetle Tenebrio molitor. The no observed effect concentration (NOEC) for imidacloprid was estimated to be between 0.001 and 0.010 microM. A concentration of 0.10 microM caused hyperexcitation in firing of the respiratory motoneurons, while the concentration of 1.00 microM caused an abrupt increase in their frequency and then a complete inhibition of the activity of the respiratory motoneurons. The possible implication of the action of such low concentrations of imidacloprid in the contraction of the respiratory muscles is also demonstrated and discussed.

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