PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond?

Article Details

Citation

Rommel C, Camps M, Ji H

PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond?

Nat Rev Immunol. 2007 Mar;7(3):191-201. Epub 2007 Feb 9.

PubMed ID
17290298 [ View in PubMed
]
Abstract

Dysregulated signal transduction in innate and adaptive immune cells is known to be associated with the development of various autoimmune and inflammatory diseases. Consequently, targeting intracellular signalling of the pro-inflammatory cytokine network heralds hope for the next generation of anti-inflammatory drugs. Phosphoinositide 3-kinases (PI3Ks) generate lipid-based second messengers that control an array of intracellular signalling pathways that are known to have important roles in leukocytes. In light of the recent progress in the development of selective PI3K inhibitors, and the beneficial effects of these inhibitors in models of acute and chronic inflammatory disorders, we discuss the therapeutic potential of blocking PI3K isoforms for the treatment of rheumatoid arthritis and other immune-mediated diseases.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoformP48736Details
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformO00329Details