Immune responses of chickens fed the androgen analog mibolerone.

Article Details

Citation
Copy to clipboard

Romero CH, Purchase HG, Frank F, Burmester BR, Kakuk TJ, Chang TS

Immune responses of chickens fed the androgen analog mibolerone.

Avian Dis. 1977 Apr-Jun;21(2):264-79.

PubMed ID
405963 [ View in PubMed
]
Abstract

Mibolerone, an androgen analog (17 beta-hydroxy-7-alpha, 17-dimethylestr-4-en-3-one), induces a slow but progressive involution of the bursa of Fabricius when fed to chickens at microng levels during the first 7 weeks of life. Chickens receiving mibolerone remained immunologically competent, evidenced by: 1) their antibody response to nonreplicating antigens and infectious antigens; 2) the number of antibody-producing cells in their spleens; 3) the stimulation of their peripheral leukocytes with the plant mitogen phytohemagglutinin; and 4) their capacity to resist challenge with Marek's disease virus and Newcastle disease virus after vaccinations with turkey herpes-virus and the B-1 LaSota strain. This, coupled with the fact that it prevents experimental lymphoid leukosis, makes mibolerone a potential agent to be used under field conditions for the control of lymphoid leukosis.

DrugBank Data that Cites this Article

Drugs