Biological evaluation of mibolerone in the female Beagle.

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Sokolowski JH, Geng S

Biological evaluation of mibolerone in the female Beagle.

Am J Vet Res. 1977 Sep;38(9):1371-6.

PubMed ID
921032 [ View in PubMed
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Abstract

Mibolerone effectively inhibited estrous activity in immature or mature Beagle bitches given 60 and 200 microgram, respectively, daily for up to 730 days. A dose level of 20 microgram of mibolerone daily was 70% effective in preventing estrus. Effects of mibolerone included estrus inhibition prolongation of the interestrous interval in bitches given 20 microgram of the mibolerone daily, vaginal discharge, and a dose-related increase in clitoral size. A decrease in posttreatment conception rate was observed only in bitches receiving 20 microgram of mibolerone daily for 730 days. Pups born to bitches conceiving after mibolerone treatment were grossly normal.

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