[Comparison of the binding nature of mibolerone to androgen receptor of human prostate with that of R1881].

Article Details

Citation
Copy to clipboard

Miki H, Oshimo K, Inoue H, Sumi T, Yamashita K, Morimoto T, Monden Y

[Comparison of the binding nature of mibolerone to androgen receptor of human prostate with that of R1881].

Nihon Naibunpi Gakkai Zasshi. 1988 Aug 20;64(8):655-65.

PubMed ID
3265669 [ View in PubMed
]
Abstract

The authors examined the binding nature of mibolerone in cytosols of hypertrophic prostates from 15 patients to androgen receptor using Dextran-charcoal assay, analyzed it by the method of Scatchard, and compared it with that of R1881. The addition of triamcinolone acetonide into the incubation medium induced specific single binding of mibolerone to androgen receptor with high affinity as well as R1881. The receptor contents obtained with mibolerone were higher than those of R1881, and both of them correlated well. The dissociation constants of both ligands showed good correlation and no significant differences. Mibolerone seems to be as suitable a ligand as R1881 for measuring the androgen receptor.

DrugBank Data that Cites this Article

Drugs