Protein kinase C and beyond.

Article Details

Citation

Spitaler M, Cantrell DA

Protein kinase C and beyond.

Nat Immunol. 2004 Aug;5(8):785-90.

PubMed ID
15282562 [ View in PubMed
]
Abstract

Protein kinase C molecules regulate both positive and negative signal transduction pathways essential for the initiation and homeostasis of immune responses. There are multiple isoforms of protein kinase C that are activated differently by calcium and diacylglycerol, and these are activated mainly by antigen receptors in T cells, B cells and mast cells. Additionally, mammals express several other diacylglycerol binding proteins that are linked to a network of key signal transduction pathways that control lymphocyte biology. Diacylglycerol and protein kinase C regulate a broad range of gene transcription programs but also modulate integrins, chemokine responses and antigen receptors, thereby regulating lymphocyte adhesion, migration, differentiation and proliferation.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Protein kinase C theta typeQ04759Details