c-Abl and Src-family kinases cross-talk in regulation of myeloid cell migration.
Article Details
- CitationCopy to clipboard
Baruzzi A, Iacobucci I, Soverini S, Lowell CA, Martinelli G, Berton G
c-Abl and Src-family kinases cross-talk in regulation of myeloid cell migration.
FEBS Lett. 2010 Jan 4;584(1):15-21. doi: 10.1016/j.febslet.2009.11.009. Epub .
- PubMed ID
- 19903482 [ View in PubMed]
- Abstract
Cytoskeleton dynamics are regulated by Src-family tyrosine kinases (SFKs) and c-Abl. We found that the SFK members Hck and c-Fgr regulate tyrosine phosphorylation of c-Abl and c-Abl associates with beta1 integrin-bound Hck or c-Fgr in murine macrophages. Studies with selective inhibitors and cells from SFK-deficient mice showed that c-Abl and SFK regulate migration and activation of the small GTPases Cdc42 and Rac in macrophages. Additionally, human neutrophil chemotactic activity was reduced by c-Abl inhibitors, and neutrophils from chronic myeloid leukaemia patients displayed an increased chemotactic ability. Hence, Src-family kinase and c-Abl cross-talk in the regulation of myeloid cell migration.