Susceptibility of rapidly growing mycobacteria and Nocardia isolates from cats and dogs to pradofloxacin.

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Govendir M, Norris JM, Hansen T, Wigney DI, Muscatello G, Trott DJ, Malik R

Susceptibility of rapidly growing mycobacteria and Nocardia isolates from cats and dogs to pradofloxacin.

Vet Microbiol. 2011 Dec 15;153(3-4):240-5. doi: 10.1016/j.vetmic.2011.06.001. Epub 2011 Jun 15.

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21726965 [ View in PubMed
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Abstract

Rapidly growing mycobacteria (RGM) and Nocardiae can cause severe or refractory infections in cats and dogs. Prolonged antibacterial therapy is required to cure these infections. As fluoroquinolones have been used in combination therapy for treating RGM infections, isolates from the Mycobacterium smegmatis cluster (n=64), Mycobacterium fortuitum cluster (n=17), and M. mageritense cluster (n=2), collected from feline and canine patients, underwent susceptibility testing to pradofloxacin. The MIC(50), MIC(90) and tentative epidemiological cut-off (ECOFF) values as determined by microbroth dilution susceptibility testing that inhibited growth of the M. smegmatis and M. fortuitum clusters were 0.063, 0.125 and

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