Induction of apoptosis in AK-5 cells by rotenone involves participation of caspases.

Article Details

Citation
Copy to clipboard

Khar A, Ali AM, Begum Z, Pardhasaradhi BV, Varalakshmi C

Induction of apoptosis in AK-5 cells by rotenone involves participation of caspases.

Indian J Biochem Biophys. 1999 Apr;36(2):77-81.

PubMed ID
10549166 [ View in PubMed
]
Abstract

AK-5 tumour cells undergo apoptosis after treatment with rotenone an electron transport inhibitor and oligomycin which inhibits mitochondrial ATPases. Apoptotic process involves the induction of caspases 2 and 3, whereas caspase 1 does not seem to be participating in rotenone/oligomycin induced apoptosis. DEVD which is a specific inhibitor of caspase 3, inhibited apoptosis in AK-5 cells. We have also observed a significant lowering of intracellular pH in AK-5 cells which are induced into the apoptotic process by rotenone. These results suggest an important role for mitochondrial electron transport in the induction of apoptosis in AK-5 tumour cells.

DrugBank Data that Cites this Article

Drugs