Rational design of potent, bioavailable, nonpeptide cyclic ureas as HIV protease inhibitors.
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Lam PY, Jadhav PK, Eyermann CJ, Hodge CN, Ru Y, Bacheler LT, Meek JL, Otto MJ, Rayner MM, Wong YN, et al.
Rational design of potent, bioavailable, nonpeptide cyclic ureas as HIV protease inhibitors.
Science. 1994 Jan 21;263(5145):380-4.
- PubMed ID
- 8278812 [ View in PubMed]
- Abstract
Mechanistic information and structure-based design methods have been used to design a series of nonpeptide cyclic ureas that are potent inhibitors of human immunodeficiency virus (HIV) protease and HIV replication. A fundamental feature of these inhibitors is the cyclic urea carbonyl oxygen that mimics the hydrogen-bonding features of a key structural water molecule. The success of the design in both displacing and mimicking the structural water molecule was confirmed by x-ray crystallographic studies. Highly selective, preorganized inhibitors with relatively low molecular weight and high oral bioavailability were synthesized.