Chemical modification of tylosin.

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Bobillot S, Bakos T, Sarda P, Thang TT, Ming L, Olesker A, Lukacs G

Chemical modification of tylosin.

J Antibiot (Tokyo). 1995 Jul;48(7):667-70.

PubMed ID
7649866 [ View in PubMed
]
Abstract

20-Homo tylosin, 20-nor tylosin, 20-deoxy-19,20-didehydro tylosin (6-vinyl tylosin) and 2",3"-didehydro-3"-deoxy tylosin were prepared by multi-step procedures. 20-Homo tylosin was about twice less active than tylosin while the other compounds exhibited very weak antibacterial activity.

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