Human factor B. Complete cDNA sequence of the BF*S allele.

Article Details


Mejia JE, Jahn I, de la Salle H, Hauptmann G

Human factor B. Complete cDNA sequence of the BF*S allele.

Hum Immunol. 1994 Jan;39(1):49-53.

PubMed ID
8181962 [ View in PubMed

The gene of human complement factor B (BF) is located within the class III region of the major histocompatibility complex. The knowledge of the coding sequence of the BF gene rests on a set of partial sequence studies reported by various sources, and full-length sequences ascribed to specific alleles of this polymorphic complement component have not yet been published. Now, we have isolated and sequenced a collection of cDNA clones derived from BF*S, the major BF allele. We present an uninterrupted, allele-specific sequence of the entire coding region and the 3' untranslated segment of the cDNA. Extensive comparison of this and previously available sequence data was carried out, and a number of base substitutions were observed in relation to some of the earlier sequences. The possibility that these differences arise from polymorphism in the BF gene is discussed.

DrugBank Data that Cites this Article

NameUniProt ID
Complement factor BP00751Details