[Inhibition of Candida albicans transformation from the yeast form to the mycelial form by 2-alkylthio-6-amino- and 2-alkylthio-6-formamido- benzothiazoles].

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Kuchta T, Strakova H, Sidoova E

[Inhibition of Candida albicans transformation from the yeast form to the mycelial form by 2-alkylthio-6-amino- and 2-alkylthio-6-formamido- benzothiazoles].

Cesk Farm. 1989 Apr;38(3):139-40.

PubMed ID
2673553 [ View in PubMed
]
Abstract

The inhibitory effectiveness of 2-alkylthio-6-amino- and 2-alkylthio-6-formamidobenzothiazoles (19 derivatives altogether) on the transformation of the yeast-like form of Candida albicans into the mycelial form (1 strain from the collection and 2 clinical isolates) was investigated. Most derivatives tested, similarly as the standard 2-mercaptobenzothiazole (Dermacid), did not exert any difference between the inhibitory effectiveness on filamentation and the inhibition of the growth and reproduction of the yeast-like form. However, the best derivative, 6-amino-2-n-pentylthiobenzothiazole, showed as much as 25-fold higher inhibitory effectiveness on the transformation of the yeast-like form into the mycelial one than MIC.

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