Death-associated protein kinase (DAPK) and signal transduction: additional roles beyond cell death.

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Citation

Lin Y, Hupp TR, Stevens C

Death-associated protein kinase (DAPK) and signal transduction: additional roles beyond cell death.

FEBS J. 2010 Jan;277(1):48-57. doi: 10.1111/j.1742-4658.2009.07411.x. Epub 2009 Oct 26.

PubMed ID
19878313 [ View in PubMed
]
Abstract

Death-associated protein kinase (DAPK) is a stress-regulated protein kinase that mediates a range of processes, including signal-induced cell death and autophagy. Although the kinase domain of DAPK has a range of substrates that mediate its signalling, the additional protein interaction domains of DAPK are relatively ill defined. This review will summarize our current knowledge of the DAPK interactome, the use of peptide aptamers to define novel protein-protein interaction motifs, and how these new protein-protein interactions give insight into DAPK functions in diverse cellular processes, including growth factor signalling, the regulation of autophagy, and its emerging role in the regulation of immune responses.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Death-associated protein kinase 1P53355Details