Cloning of a cDNA encoding the human transforming growth factor-beta type II receptor: heterogeneity of the mRNA.
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Ogasa H, Noma T, Murata H, Kawai S, Nakazawa A
Cloning of a cDNA encoding the human transforming growth factor-beta type II receptor: heterogeneity of the mRNA.
Gene. 1996 Nov 28;181(1-2):185-90.
- PubMed ID
- 8973329 [ View in PubMed]
- Abstract
We have isolated two novel cDNAs encoding the transforming growth factor-beta (TGF-beta) type II receptor (TGF-beta IIR), termed TGF-beta IIR alpha and TGF-beta IIR beta 1 from a human fetal liver library. They have unique nucleotide (nt) sequences, compared with the reported TGF-beta IIR sequence, at the 5' end. Southern blot analysis using probes from each clone detected the specific genomic DNA fragments. RT-PCR analysis revealed a distinct pattern of expression for each isoform. These results indicated that TGF-beta IIR has heterogeneity in the structure, and the expression of TGF-beta IIR isoforms is differentially regulated. The heterogeneity of TGF-beta IIR molecules could be derived from alternative splicing and might elicit specific TGF-beta receptor functions.