Effects of melengestrol acetate on reproduction in the Beagle bitch.

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Sokolowski JH, VanRavenswaay F

Effects of melengestrol acetate on reproduction in the Beagle bitch.

Am J Vet Res. 1976 Aug;37(8):943-5.

PubMed ID
949121 [ View in PubMed
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Abstract

Melengestrol acetate orally given to bitches at dose levels of 200 mug or more each day effectively inhibited estrous activity for a treatment period of 243 days and a lapsed period of more than 400 days from the preceding estrous period. The 100-mug dose of the drug, given orally once a day, starting immediately after the bitches were bred or late in gestation, had no effect on conception, pregnancy, or parturition. Gestation was prolonged in bitches given melengestrol acetate starting 1 day after breeding. Drug-polymeric implants blocked reproductive activity, and the progestogen induced cystic endometrial hyperplasia.

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