Increased homocyst(e)ine associated with smoking, chronic inflammation, and aging may reflect acute-phase induction of pyridoxal phosphatase activity.
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McCarty MF
Increased homocyst(e)ine associated with smoking, chronic inflammation, and aging may reflect acute-phase induction of pyridoxal phosphatase activity.
Med Hypotheses. 2000 Oct;55(4):289-93.
- PubMed ID
- 11000053 [ View in PubMed]
- Abstract
Smokers, patients with chronic inflammatory disorders, and the elderly, are characterized by increased production of IL-6 as well as increased plasma levels of homocyst(e)ine. Analysis of cirrhotic livers suggests that IL-6 may stimulate the activity of pyridoxal phosphatase in hepatocytes, thereby diminishing pyridoxal phosphate levels, compromising cystathionine beta-synthase activity, and raising plasma homocyst(e)ine. Adequate supplemental intakes of pyridoxine may be corrective in this regard.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Pyridoxal phosphate Pyridoxal phosphate phosphatase Protein Humans UnknownCofactorDetails