A clinical drug library screen identifies astemizole as an antimalarial agent.
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Chong CR, Chen X, Shi L, Liu JO, Sullivan DJ Jr
A clinical drug library screen identifies astemizole as an antimalarial agent.
Nat Chem Biol. 2006 Aug;2(8):415-6. Epub 2006 Jul 2.
- PubMed ID
- 16816845 [ View in PubMed]
- Abstract
The high cost and protracted time line of new drug discovery are major roadblocks to creating therapies for neglected diseases. To accelerate drug discovery we created a library of 2,687 existing drugs and screened for inhibitors of the human malaria parasite Plasmodium falciparum. The antihistamine astemizole and its principal human metabolite are promising new inhibitors of chloroquine-sensitive and multidrug-resistant parasites, and they show efficacy in two mouse models of malaria.
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