Studies on experimentally induced hyperphenylalaninemia.

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Pueschel SM, Boylan J, Ellenbogen R

Studies on experimentally induced hyperphenylalaninemia.

J Ment Defic Res. 1988 Aug;32 ( Pt 4):309-19.

PubMed ID
2975336 [ View in PubMed
]
Abstract

The administration of several compounds that can increase plasma phenylalanine levels and/or inhibit phenylalanine hydroxylase in rats was studied in order to determine their usefulness in inducing a phenylketonuria-like state. The results of this investigation revealed that 4.5 microns/10 g p-chlorophenylalanine is more effective than L-phenylalanine, alpha-methylphenylalanine, trimethoprim, Bactrim and Septra, since the former compound produced both adequate hyperphenylalaninemia and marked inhibition of hepatic phenylalanine hydroxylase activity. In addition, a 24-h study provided important insights into the changing diurnal patterns of specified biochemical parameters.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
PhenylalaninePhenylalanine-4-hydroxylaseProteinHumans
Unknown
Not AvailableDetails