Phenylalanine as substrate for tyrosine hydroxylase in bovine adrenal chromaffin cells.
Article Details
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Fukami MH, Haavik J, Flatmark T
Phenylalanine as substrate for tyrosine hydroxylase in bovine adrenal chromaffin cells.
Biochem J. 1990 Jun 1;268(2):525-8.
- PubMed ID
- 1973034 [ View in PubMed]
- Abstract
Incubation of bovine chromaffin cells with L-[14C]phenylalanine resulted in label accumulation in catecholamines at about 30% of the rate seen with L-tyrosine as precursor. Studies with purified tyrosine hydroxylase (EC 1.14.16.2) showed that the enzyme catalysed the hydroxylation of L-phenylalanine first to L-p-tyrosine and then to 3,4-dihydroxyphenylalanine (DOPA). No evidence for a significant involvement of an L-m-tyrosine intermediate in DOPA formation was found.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Phenylalanine Tyrosine 3-monooxygenase Protein Humans UnknownBinderDetails