Phenylalanine as substrate for tyrosine hydroxylase in bovine adrenal chromaffin cells.

Article Details

Citation

Fukami MH, Haavik J, Flatmark T

Phenylalanine as substrate for tyrosine hydroxylase in bovine adrenal chromaffin cells.

Biochem J. 1990 Jun 1;268(2):525-8.

PubMed ID
1973034 [ View in PubMed
]
Abstract

Incubation of bovine chromaffin cells with L-[14C]phenylalanine resulted in label accumulation in catecholamines at about 30% of the rate seen with L-tyrosine as precursor. Studies with purified tyrosine hydroxylase (EC 1.14.16.2) showed that the enzyme catalysed the hydroxylation of L-phenylalanine first to L-p-tyrosine and then to 3,4-dihydroxyphenylalanine (DOPA). No evidence for a significant involvement of an L-m-tyrosine intermediate in DOPA formation was found.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
PhenylalanineTyrosine 3-monooxygenaseProteinHumans
Unknown
Binder
Details