Crystal structure of the human leukocyte Fc receptor, Fc gammaRIIa.

Article Details

Citation

Maxwell KF, Powell MS, Hulett MD, Barton PA, McKenzie IF, Garrett TP, Hogarth PM

Crystal structure of the human leukocyte Fc receptor, Fc gammaRIIa.

Nat Struct Biol. 1999 May;6(5):437-42.

PubMed ID
10331870 [ View in PubMed
]
Abstract

Fc gamma receptors bind IgG to initiate cellular responses against pathogens and soluble antigens. We have determined the three-dimensional structure of the extracellular portion of human Fc gammaRIIa to 2.0 A resolution providing a structural basis for the unique functions of the leukocyte FcR family. The receptor is composed of two immunoglobulin domains and arranged to expose the ligand-binding site at one end of domain 2. Using alanine mutants we find that the binding sites for IgG1 and 2 are similar but the relative importance of specific regions on the receptor varies. In crystals, Fc gammaRIIa molecules associate to resemble V(L)V(H) dimers, suggesting that two Fc gammaRIIa molecules could cooperate to bind IgG in an asymmetric manner.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Low affinity immunoglobulin gamma Fc region receptor II-aP12318Details