LDL receptor-related proteins in neurodevelopment.

Article Details

Citation

May P, Herz J

LDL receptor-related proteins in neurodevelopment.

Traffic. 2003 May;4(5):291-301.

PubMed ID
12713657 [ View in PubMed
]
Abstract

Low-density lipoprotein receptor-related proteins (LRPs) are evolutionarily ancient cell-surface receptors with diverse biological functions. All are expressed in the central nervous system and, for most receptors, animal models have shown that they are indispensable for successful neurodevelopment. The mechanisms by which they regulate the formation of the nervous system are varied and include the transduction of extracellular signals and the modulation of intracellular signal propagation, as well as cargo transport, the function most commonly attributed to this gene family. Here, we will summarize recent advances in our understanding of the molecular basis on which these receptors function during development.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Prolow-density lipoprotein receptor-related protein 1Q07954Details