MHC class II molecules on the move for successful antigen presentation.

Article Details

Citation

Rocha N, Neefjes J

MHC class II molecules on the move for successful antigen presentation.

EMBO J. 2008 Jan 9;27(1):1-5. Epub 2007 Nov 29.

PubMed ID
18046453 [ View in PubMed
]
Abstract

Major histocompatibility complex class II (MHC II) molecules are targeted to endocytic compartments, known as MIIC, by the invariant chain (Ii) that is degraded upon arrival in these compartments. MHC II acquire antigenic fragments from endocytosed proteins for presentation at the cell surface. In a unique and complex series of reactions, MHC II succeed in exchanging a remaining fragment of Ii for other protein fragments in subdomains of MIIC before transport to the cell surface. Here, the mechanisms regulating loading and intracellular trafficking of MHC II are discussed.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
HLA class II histocompatibility antigen, DQ alpha 2 chainP01906Details
HLA class II histocompatibility antigen, DQ beta 1 chainP01920Details
HLA class II histocompatibility antigen, DR alpha chainP01903Details
HLA class II histocompatibility antigen, DRB1-15 beta chainP01911Details
HLA class II histocompatibility antigen, DR beta 3 chainP79483Details
HLA class II histocompatibility antigen, DR beta 4 chainP13762Details
HLA class II histocompatibility antigen, DR beta 5 chainQ30154Details