MHC class II molecules on the move for successful antigen presentation.
Article Details
- CitationCopy to clipboard
Rocha N, Neefjes J
MHC class II molecules on the move for successful antigen presentation.
EMBO J. 2008 Jan 9;27(1):1-5. Epub 2007 Nov 29.
- PubMed ID
- 18046453 [ View in PubMed]
- Abstract
Major histocompatibility complex class II (MHC II) molecules are targeted to endocytic compartments, known as MIIC, by the invariant chain (Ii) that is degraded upon arrival in these compartments. MHC II acquire antigenic fragments from endocytosed proteins for presentation at the cell surface. In a unique and complex series of reactions, MHC II succeed in exchanging a remaining fragment of Ii for other protein fragments in subdomains of MIIC before transport to the cell surface. Here, the mechanisms regulating loading and intracellular trafficking of MHC II are discussed.
DrugBank Data that Cites this Article
- Polypeptides
Name UniProt ID HLA class II histocompatibility antigen, DQ alpha 2 chain P01906 Details HLA class II histocompatibility antigen, DQ beta 1 chain P01920 Details HLA class II histocompatibility antigen, DR alpha chain P01903 Details HLA class II histocompatibility antigen, DRB1-15 beta chain P01911 Details HLA class II histocompatibility antigen, DR beta 3 chain P79483 Details HLA class II histocompatibility antigen, DR beta 4 chain P13762 Details HLA class II histocompatibility antigen, DR beta 5 chain Q30154 Details