[5'-adenosine monophosphate-activated protein kinase and lifestyle-mediated diseases].

Article Details

Citation

Copy to clipboard

Richter EA, Kiens B, Wojtaszewski JF

[5'-adenosine monophosphate-activated protein kinase and lifestyle-mediated diseases].

Ugeskr Laeger. 2006 Feb 27;168(9):896-900.

PubMed ID

16513051 [ View in PubMed

]

Abstract

5'-adenosine monophosphate-activated protein kinase (AMPK) is an enzyme activated when cellular energy status is threatened. AMPK activates energy-providing processes, while energy-consuming processes are inhibited. AMPK is also involved in regulation of gene expression and in appetite control. Pharmacological activation of AMPK in animal models of the metabolic syndrome leads to marked amelioration of symptoms. Some antidiabetic drugs activate AMPK, and activation also occurs during physical exercise. It is likely that part of the effect of physical activity in preventing the development of diseases related to a sedentary lifestyle is due to activation of AMPK.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Adenosine phosphate	5'-AMP-activated protein kinase subunit beta-1	Protein	Humans	Unknown	Activator	Details