The choice between alternative IIIb and IIIc exons of the FGFR-3 gene is not strictly tissue-specific.
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Scotet E, Houssaint E
The choice between alternative IIIb and IIIc exons of the FGFR-3 gene is not strictly tissue-specific.
Biochim Biophys Acta. 1995 Nov 7;1264(2):238-42.
- PubMed ID
- 7495869 [ View in PubMed]
- Abstract
An essential feature of fibroblast growth factor receptors (FGFR) is the existence of multiple possibilities for alternative splicing. One of these concerns sequences of the mRNA coding for the C-terminal half of Ig domain 3 which corresponds to a part of the ligand-binding site. Two alternative exons, IIIb and IIIc, encode the C-terminal half of Ig domain 3. We show here that the alternative splicing choice between IIIb and IIIc exons of the FGFR-3 is not strictly tissue-specific: epithelial cells show exclusively IIIb transcripts while fibroblastic cells show a mixture of IIIb and IIIc transcripts. This is in contrast with the strictly exclusive alternative choice between IIIb or IIIc exons of the FGFR-2 gene: epithelial cells make only the IIIb choice while fibroblastic cells make only the IIIc choice.