Influence of altered gravity on brain cellular energy and plasma membrane metabolism of developing lower aquatic vertebrates.
Article Details
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Slenzka K, Appel R, Kappel Th, Rahmann H
Influence of altered gravity on brain cellular energy and plasma membrane metabolism of developing lower aquatic vertebrates.
Adv Space Res. 1996;17(6-7):125-8.
- PubMed ID
- 11538605 [ View in PubMed]
- Abstract
Biochemical analyses of the brain of cichlid fish larvae, exposed for 7 days to increased acceleration of 3g (hyper-g), revealed an increase in energy availability (succinate dehydrogenase activity, SDH), and in mitochondrial energy transformation (creatine kinase, Mia-CK), but no changes in an energy consumptive process (high-affinity Ca(2+)-ATPase). Brain glucose-6-phosphate dehydrogenase (G6PDH) of developing fish was previously found to be increased after hyper-g exposure. Three respectively 5 hours thereafter dramatic fluctuations in enzyme activity were registered. Analysing the cytosolic or plasma membrane-located brain creatine kinase (BB-CK) of clawed toad larvae after long-term hyper-g exposure a significant increase in enzyme activity was demonstrated, whereas the activity of a high affinity Ca(2+)-ATPase remained unaffected.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Creatine Creatine kinase U-type, mitochondrial Protein Humans YesLigandDetails Phosphocreatine Creatine kinase U-type, mitochondrial Protein Humans YesLigandDetails