Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor.
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Ishikawa F, Miyazono K, Hellman U, Drexler H, Wernstedt C, Hagiwara K, Usuki K, Takaku F, Risau W, Heldin CH
Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor.
Nature. 1989 Apr 13;338(6216):557-62.
- PubMed ID
- 2467210 [ View in PubMed]
- Abstract
Cloning and sequencing of the complementary DNA for platelet-derived endothelial cell growth factor indicates that it is a novel factor distinct from previously characterized proteins. The factor, a protein with a relative molecular mass of about 45,000, stimulates endothelial cell growth and chemotaxis in vitro and angiogenesis in vivo.