HIV-1 protease
Details
- Name
- HIV-1 protease
- Kind
- protein
- Synonyms
- Fragment
- Gene Name
- HIV-1 protease
- UniProtKB Entry
- O90777TrEMBL
- Organism
- Human Immunodeficiency Virus
- NCBI Taxonomy ID
- 12721
- Amino acid sequence
>lcl|BSEQ0010463|HIV-1 protease PQVTLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMSLPGKWKPKMIGGIGGFIKVRQYD QVSIEICGHKAIGTVLIGPTPVNIIGRNLLTQLGCTLNF
- Number of residues
- 99
- Molecular Weight
- 10724.61
- Theoretical pI
- 8.77
- GO Classification
- Functionsaspartic-type endopeptidase activity
- General Function
- Aspartic-type endopeptidase activity
- Specific Function
- Not Available
- Pfam Domain Function
- RVP (PF00077)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0001323|297 bp CCTCAGGTCACTCTTTGGCAACGACCCATAGTCACAATAAAGATAGGGGGGCAACTAAAG GAAGCTCTATTAGATACAGGAGCAGATGATACAGTATTAGAAGAAATGAGTTTGCCAGGA AAATGGAAACCAAAAATGATAGGGGGAATTGGAGGTTTTATCAAAGTAAGACAGTATGAT CAGGTATCCATAGAAATCTGCGGACATAAAGCTATAGGTACAGTATTAATAGGACCTACA CCTGTCAACATAATTGGAAGGAATCTGTTGACTCAGCTTGGCTGCACTTTAAATTTT
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID O90777 UniProtKB Entry Name O90777_9PLVG GenBank Protein ID 4377614 GenBank Gene ID AJ010714 - General References
- Servais J, Lambert C, Fontaine E, Plesseria JM, Robert I, Arendt V, Staub T, Schneider F, Hemmer R, Burtonboy G, Schmit JC: Variant human immunodeficiency virus type 1 proteases and response to combination therapy including a protease inhibitor. Antimicrob Agents Chemother. 2001 Mar;45(3):893-900. [Article]
- Servais J, Lambert C, Fontaine E, Plesseria JM, Robert I, Arendt V, Staub T, Schneider F, Hemmer R, Burtonboy G, Schmit JC: Comparison of DNA sequencing and a line probe assay for detection of human immunodeficiency virus type 1 drug resistance mutations in patients failing highly active antiretroviral therapy. J Clin Microbiol. 2001 Feb;39(2):454-9. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Nelfinavir approved yes target inhibitor Details TMC-310911 investigational unknown target inhibitor Details