- Xanthine derivatives
- Accession Number
- DBCAT001034 (DBCAT000503, DBCAT001028, DBCAT001220, DBCAT002203, DBCAT002692, DBCAT003295)
A methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Theophylline inhibits the 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE that degrades CYCLIC AMP thus potentiates the actions of agents that act through ADENYLYL CYCLASES and cyclic AMP.
- ATC Classification
Drug Drug Description Oxtriphylline A bronchodilator used for the treatment of asthma, bronchitis, COPD, and emphysema. Doxofylline A methylxanthine derivative used in chronic obstructive pulmonary disease, asthma, and bronchospasms. Bamifylline A methylxanthine derivative indicated in the treatment of bronchial asthma and other conditions with bronchospasm. Acefylline Not Annotated Bufylline Not Annotated Fenethylline Not Available Proxyphylline Not Annotated Bromotheophylline Bromotheophylline is used as a diuretic and also, in combination with DB00316, it is used for the relief of temporary water weight gain, bloating, swelling and full feeling associated with... Pentoxifylline A methylxanthine derivative used to treat intermittent claudication caused by chronic occlusive arterial disease of the limbs. 8-azaguanine 8-azaguanine is one of the early purine analogs showing antineoplastic activity. It functions as an antimetabolite and is easily incorporated into ribonucleic acids. 7,9-Dimethylguanine Not Available Xanthine A drug used to manage uncomplicated liver dysfunction in combination with orotic acid. 7-Deazaguanine Not Available Guanine Not Available 9-Methylguanine Not Available Peldesine Peldesine is a potent inhibitor of human CCRF-CEM T-cell proliferation. It has undergone phase I trials for the treatment of Human Immunodeficiency Virus (HIV) infections. Hypoxanthine Hypoxanthine is a purine and a reaction intermediate in the metabolism of adenosine and in the formation of nucleic acids by the salvage pathway. 9-Deazaguanine Not Available Valomaciclovir Investigated for use/treatment in herpes zoster infections and viral infection. 3-isobutyl-1-methyl-7H-xanthine Not Available Uric acid At present (August 2013), there is no approved indication for uric acid. The potential therapeutic use for uric acid is as an adjunct in acute ischemic stroke. 6-O-benzylguanine 6-O-benzylguanine has been used in trials studying the treatment of HIV Infection, Adult Gliosarcoma, Adult Glioblastoma, Stage I Adult Hodgkin Lymphoma, and Stage II Adult Hodgkin Lymphoma, among others. Lisofylline Lisofylline has been investigated for the treatment of Type 1 Diabetes Mellitus. Lobucavir Lobucavir has been used in trials studying the treatment of HIV Infections and Cytomegalovirus Infections. Cafedrine Cafedrine is under investigation in clinical trial NCT01311414 (Effect of Cafedrine/Theodrenaline and Urapidil on Cerebral Oxygenation). Theodrenaline Theodrenaline is under investigation in clinical trial NCT01311414 (Effect of Cafedrine/Theodrenaline and Urapidil on Cerebral Oxygenation). Etamiphylline Not Annotated Pentifylline Not Annotated Furafylline Furafylline is a derivative of methylxanthine derivative. It was developed on the context of asthma as a long-acting alternative for theophylline. Theobromine theobromine is used as a vasodilator, a diuretic, and heart stimulant. And similar to caffeine, it may be useful in management of fatigue and orthostatic hypotension. Propentofylline Investigated for use/treatment in alzheimer's disease. Caffeine A stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. It is also used in to prevent and treat pulmonary complications of premature birth. 8-chlorotheophylline When used in combination with DB01075 as the antiemetic DB00985, 8-chlorotheophylline is indicated for the prevention and treatment of nausea, vomiting, or vertigo of motion sickness. Theophylline A xanthine used to manage the symptoms of asthma, COPD, and other lung conditions caused by reversible airflow obstruction. Dyphylline A theophylline derivative used to treat asthma, bronchospasm, and COPD. Aminophylline A bronchodilator consisting of theophylline that is used for the treatment of bronchospasm due to asthma, emphysema and chronic bronchitis. Mercaptopurine An antineoplastic agent used to treat acute lymphocytic leukemia. PCS-499 PCS-499 is under investigation in clinical trial NCT01487109 (A Phase 2 Study to Evaluate the Safety and Efficacy of CTP-499 in Type 2 Diabetic Nephropathy Patients). 7-cyano-7-deazaguanine Not Available 5'-S-methyl-5'-thioadenosine Not Available Valomaciclovir stearate Valomaciclovir stearate is under investigation in clinical trial NCT00831103 (A Phase 2b Trial of EPB-348 for the Treatment of Herpes Zoster). Besifovir dipivoxil Investigated for use/treatment in hepatitis (viral, B). Besifovir Not Annotated
- Drugs & Drug Targets