Cluster Headache (DBCOND0003590)

Identifiers

Synonyms

Cluster headaches / Cluster headache / Chronic cluster headache / Cluster headache syndrome, unspecified / Chronic cluster headache, not intractable / Cluster headache syndrome, unspecified, not intractable / Cluster headaches and other trigeminal autonomic cephalgias (TAC) / Headache histamine / Horton's headache / Headache vasomotor / Migrainous neuralgia / Ciliary neuralgia (finding) / Chronic cluster headache (disorder) / Cluster headache syndrome (disorder) / Headaches cluster

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Dihydroergotamine	An ergot alkaloid used in the acute treatment of migraine headache and cluster headache.	5-hydroxytryptamine receptor 1Dtarget 5-hydroxytryptamine receptor 1Btarget Cytochrome P450 3A4enzyme Alpha-2A adrenergic receptortarget 5-hydroxytryptamine receptor 2Btarget ATP-dependent translocase ABCB1transporter 5-hydroxytryptamine receptor 1Atarget 5-hydroxytryptamine receptor 1Etarget 5-hydroxytryptamine receptor 2Atarget 5-hydroxytryptamine receptor 2Ctarget Alpha-1 adrenergic receptorstarget Alpha-2 adrenergic receptorstarget D(2) dopamine receptortarget D(3) dopamine receptortarget D(4) dopamine receptortarget 5-hydroxytryptamine receptor 1Ftarget 5-hydroxytryptamine receptor 4target Beta-3 adrenergic receptortarget
Ergotamine	An alpha-1 selective adrenergic agonist vasoconstrictor used to treat migraines with or without aura and cluster headaches.	Alpha-1A adrenergic receptortarget 5-hydroxytryptamine receptor 1Dtarget 5-hydroxytryptamine receptor 1Btarget 5-hydroxytryptamine receptor 2Atarget Alpha-2A adrenergic receptortarget D(2) dopamine receptortarget Cytochrome P450 3A4enzyme Alpha-1B adrenergic receptortarget Alpha-1D adrenergic receptortarget ATP-dependent translocase ABCB1transporter D(1) dopamine receptortarget 5-hydroxytryptamine receptor 1Atarget 5-hydroxytryptamine receptor 1Ftarget 5-hydroxytryptamine receptor 2Ctarget 5-hydroxytryptamine receptor 2Btarget Alpha-2C adrenergic receptortarget
Mecloxamine	A medication indicated in combination with caffeine, ergotamine, and acetaminophen for the treatment of headaches and migraines.	No drug targets
Verapamil	A non-dihydropyridine calcium channel blocker used in the treatment of angina, arrhythmia, and hypertension.	ATP-sensitive inward rectifier potassium channel 11target Voltage-dependent T-type calcium channel subunit alpha-1Gtarget Potassium voltage-gated channel subfamily H member 2target Voltage-dependent L-type calcium channel subunit alpha-1Ctarget Cytochrome P450 1A2enzyme Cytochrome P450 3A5enzyme Voltage-dependent N-type calcium channel subunit alpha-1Btarget Voltage-dependent P/Q-type calcium channel subunit alpha-1Atarget Sodium-dependent serotonin transportertarget Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Solute carrier family 22 member 1transporter ATP-binding cassette sub-family C member 3transporter ATP-binding cassette sub-family C member 4transporter Organic cation/carnitine transporter 2transporter Solute carrier organic anion transporter family member 1A2transporter ATP-binding cassette sub-family C member 10transporter Solute carrier family 22 member 4transporter Solute carrier organic anion transporter family member 1B1transporter Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2D6enzyme Alpha-1A adrenergic receptortarget Alpha-1B adrenergic receptortarget Alpha-1D adrenergic receptortarget Albumincarrier Alpha-1-acid glycoprotein 1carrier Cytochrome P450 2C18enzyme Cytochrome P450 2E1enzyme Multidrug resistance-associated protein 1transporter Multidrug and toxin extrusion protein 1transporter Multidrug and toxin extrusion protein 2transporter Voltage-dependent T-type calcium channel subunit alpha-1Htarget Voltage-dependent calcium channeltarget ATP-dependent translocase ABCB1target
Zolmitriptan	A member of the triptan class of 5-HT(1B/1D/1F) receptor agonist drugs used for the acute treatment of migraine with or without aura in adults.	5-hydroxytryptamine receptor 1Dtarget 5-hydroxytryptamine receptor 1Btarget 5-hydroxytryptamine receptor 1Ftarget Cytochrome P450 1A2enzyme Amine oxidase [flavin-containing] Aenzyme 5-hydroxytryptamine receptor 1Atarget ATP-dependent translocase ABCB1transporter 5-hydroxytryptamine receptor 7target 5-hydroxytryptamine receptor 2Atarget 5-hydroxytryptamine receptor 2Btarget 5-hydroxytryptamine receptor 1Etarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT02460003	Physiotherapy Program for Cluster Headache	No drug interventions	treatment	Not Available	unknown_status
NCT03567590	The Efficacy and Safety of Sphenopalatine Ganglion Pulsed Radiofrequency Treatment for Cluster Headache	No drug interventions	treatment	Not Available	completed
NCT01395264	Saccadometry in Primary Headache Syndromes	No drug interventions	Not Available	Not Available	terminated
NCT01298921	A Pilot Study of Demand Valve Oxygen Inhalation Therapy for Cluster Headache	Oxygen	treatment	1	terminated
NCT00184587	Prophylactic Treatment of Episodic Cluster Headache	Angiotensin II Candesartan cilexetil	treatment	2	completed
NCT02853487	Circadian Rhythm and Attack-timing in Episodic Cluster Headache Patients in- and Outside of Bout: an Actigraphic Study	No drug interventions	Not Available	Not Available	completed
NCT02782533	DBS of the Third Ventricle for Cluster Headache and Obesity	No drug interventions	treatment	Not Available	completed
NCT06540651	Efficacy of Light Therapy in Treatment of Chronic Cluster Headache	No drug interventions	treatment	Not Available	not_yet_recruiting
NCT03781128	Lysergic Acid Diethylamide (LSD) as Treatment for Cluster Headache	Lysergic acid diethylamide	treatment	2	recruiting
NCT06011811	Cluster Headache Treatment Survey	No drug interventions	Not Available	Not Available	active_not_recruiting
NCT04439409	Variability of the Autonomic Nervous System (ANS) During Cluster Headache (CH).	No drug interventions	Not Available	Not Available	terminated
NCT03066037	Regional-anaesthesiological Infiltration Techniques for the Management of Chronic Pain: a Retrospective Study	No drug interventions	Not Available	Not Available	completed
NCT04570475	High Dose Vitamin D Plus Multivitamin in the Prevention of Cluster Headache	Vitamin D	treatment	3	terminated
NCT00203242	An Open Label Study Using Consecutive Intravenous Depacon With Oral Depakote ER for the Treatment of Cluster Headaches.	Valproic acid	treatment	Not Available	completed
NCT01447641	Sleep, Circadian Rhythms and Cluster Headache	No drug interventions	Not Available	Not Available	completed
NCT02466334	CGRP's Cluster Headache Inducing Abilities in Cluster Headache Patients	Calcitonin gene-related peptide	basic_science	Not Available	completed
NCT06277063	nVNS for the Prevention and Treatment of Primary Headache	No drug interventions	treatment	Not Available	not_yet_recruiting
NCT03397563	Continuous Positive Airway Pressure as a Potential New Treatment for Cluster Headache	No drug interventions	treatment	Not Available	completed
NCT04939922	China Headache Registry Study	No drug interventions	Not Available	Not Available	recruiting
NCT02637648	Sodium Oxybate in Patients With Episodic and Chronic Cluster Headache	Sodium oxybate	treatment	3	unknown_status
NCT05324748	Repeated GON Injections in CCH	Methylprednisolone	treatment	3	recruiting
NCT01677026	Data Collection on the ATI Neurostimulation System: SPG Stimulation for Cluster Headache	No drug interventions	Not Available	Not Available	completed
NCT04179266	Effect of Ketamine Intranasal Spray in Treatment of Chronic Cluster Headache	Ketamine	treatment	1 / 2	completed
NCT03944876	Botulinum Toxin Type A Blockade of the Sphenopalatine Ganglion in Treatment-refractory Chronic Cluster Headache	Botulinum toxin type A Sodium chloride	treatment	3	recruiting
NCT05023460	Treatment of Chronic Cluster Headache With TENS and ONS	No drug interventions	treatment	Not Available	active_not_recruiting
NCT03010189	Actigraphy and Nocturnal Heartrate Variability in Cluster Headache Patients	No drug interventions	basic_science	Not Available	completed
NCT04949204	Context-awareness, Physiological Monitoring, and Machine Learning in Migraine and Cluster Headache	No drug interventions	Not Available	Not Available	completed
NCT03511846	Pain Biomarker Study	Capsaicin	basic_science	1	recruiting
NCT06583395	Quest to Analyze One Thousand Humans Meditating	No drug interventions	Not Available	Not Available	enrolling_by_invitation
NCT02381795	Pilot Study Evaluating the Use of Nasal Carbon Dioxide for the Treatment of Cluster Headache	Carbon dioxide	treatment	2	terminated
NCT04280055	Prophylactic Effects of Psilocybin on Chronic Cluster Headache	Psilocybin	treatment	1 / 2	terminated
NCT04970355	Efficacy of Erenumab in Chronic Cluster Headache	Erenumab	prevention	2	completed
NCT01898455	Intranasal Cooling for Cluster Headache and Migraine	No drug interventions	treatment	Not Available	completed
NCT05780450	Effectiveness of Transcranial Direct Current in Patients With Persistent COVID-19 With Headaches and Chronic Pain.	No drug interventions	treatment	Not Available	recruiting
NCT02910323	The Will Erwin Headache Research Center - Cluster Headache Study	No drug interventions	Not Available	Not Available	recruiting
NCT04066023	Double-Blind Comparison of the Efficacy and Safety of C213 to Placebo for the Acute Treatment of Cluster Headaches	Zolmitriptan	treatment	2 / 3	completed
NCT00203190	A Double-Blind, Placebo-Controlled Study Examining the Use of Topiramate in the Treatment of Cluster Headache	Topiramate	treatment	4	terminated
NCT04930887	Clinical Trial of Endoscopically Guided Injection of Exparel (Bupivacaine) for the Treatment of Craniofacial Pain	Bupivacaine	treatment	2	recruiting
NCT04845451	The Presence and Role of Zygomatic-temporal Neuroma Triggering Cluster Headache	No drug interventions	Not Available	Not Available	completed
NCT04409977	Circadian Changes of the Hypothalamic Activity in Patients Suffering From Cluster Headache	No drug interventions	Not Available	Not Available	unknown_status
NCT05857098	Detection of Local Field Potentials in the Ventral Tegmental Area of the Midbrain in Chronic Cluster Headache Patients	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT04467398	Incidence of Intravascular (IV) Injection During Trigeminal Nerve Blocks	No drug interventions	Not Available	Not Available	recruiting
NCT04353505	Intra-arterial Sphenopalatine Ganglion Block for Patients With Refractory Headache	Dexamethasone Ketorolac	treatment	1	withdrawn
NCT02640105	Cluster Headache, Addictions and Vascular Function	No drug interventions	Not Available	Not Available	completed
NCT02310828	The Efficacy of L-cysteine in Prevention of Cluster Headache	No drug interventions	treatment	Not Available	completed
NCT06503328	Role of Specific microRNAs in Cluster Headache	No drug interventions	Not Available	Not Available	recruiting
NCT03840928	PatientSpot Formerly Known as ArthritisPower	No drug interventions	Not Available	Not Available	recruiting
NCT02895256	Long-term Prognosis of Cluster Headache: a Retrospective Cohort Study	No drug interventions	Not Available	Not Available	unknown_status
NCT03107052	A Study to Explore the Long-Term Safety and Efficacy of Fremanezumab (TEV-48125) for the Prevention of Cluster Headache	Fremanezumab	treatment	3	terminated
NCT04406259	Atrioventricular Block and Cluster Headache (SEVA)	Verapamil	other	4	recruiting
NCT00458770	Study of Hypothalamic Metabolism in Spontaneous Cluster Headache Attacks	No drug interventions	basic_science	Not Available	terminated
NCT00329836	A Research Study to Examine Cutaneous Allodynia and Cluster Headache	No drug interventions	Not Available	Not Available	completed
NCT02019017	Botox Injection in Treatment of Cluster Headache	Botulinum toxin type A	treatment	1 / 2	completed
NCT01792817	Non-invasive Neurostimulation of the Vagus Nerve for the Treatment of Cluster Headache	No drug interventions	treatment	Not Available	completed
NCT05978258	A Close Examination of Patient Experiences in Cluster Headache Clinical Research	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT00662935	Evaluation of Efficacity and Safety of Deep Brain Stimulation (DBS) in Chronic and Treatment-Resistant Cluster Headache(CH)	No drug interventions	treatment	Not Available	completed
NCT03066635	Botulinum Toxin Type A Block of the Otic Ganglion in Chronic Cluster Headache: Safety Issues	Botulinum toxin type A Diphenhydramine	treatment	1 / 2	completed
NCT04983186	mBrain-21 : a Three-month Study on Context-awareness, Physiological Monitoring, and Machine Learning in Migraine and Cluster Headache	No drug interventions	diagnostic	Not Available	completed
NCT03439722	Sleep in Cluster Headache: Sleep Parameters in- and Outside a Cluster Bout	No drug interventions	Not Available	Not Available	completed
NCT01958125	A Randomized Multicentre Study for the Acute Relief of Episodic and Chronic Cluster Headache.	No drug interventions	treatment	Not Available	completed
NCT03377257	Efficacy and Safety of Zolmitriptan by Sublingual Administration	Zolmitriptan	treatment	4	unknown_status
NCT03814226	PACAP-38 Infusion in Patients With Cluster Headache	No drug interventions	basic_science	Not Available	unknown_status
NCT05093582	The Effects of Levcromakalim in Patients With Cluster Headache	No drug interventions	other	Not Available	completed
NCT02981173	Psilocybin for the Treatment of Cluster Headache	Psilocybin	treatment	1	completed
NCT02440776	Pathway CH S&E Registry	No drug interventions	Not Available	Not Available	unknown_status
NCT05153876	An Open Internet-based Survey and Natural Language Processing Project Analysing Written Monologues by Headache Patients	No drug interventions	Not Available	Not Available	completed
NCT06200480	Nurse Intervention Trial	No drug interventions	treatment	Not Available	recruiting
NCT06410872	Risk Taking and Decision-making in Cluster Headache Patients	No drug interventions	Not Available	Not Available	completed
NCT06206772	Resting State Functional Connectivity in Cluster Headache	No drug interventions	Not Available	Not Available	recruiting
NCT00804895	Cluster Headache Cortivazol Injection (CHCI)	Aloe vera leaf Ascorbic acid Cortivazol Glycerin Nicotinamide Verapamil Vitamin A	treatment	2 / 3	completed
NCT05264714	Cluster Headache Treatment With Rimegepant	Rimegepant	treatment	2	recruiting