Irrigation therapy (DBCOND0024693)

Identifiers

Synonyms

General irrigation / Irrigation / General irrigation therapy / Irrigation (procedure) / Lavage / Irrigation - action (qualifier value)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Calcium chloride	An ionic compound used for the treatment of hypocalcemia and hyperkalemia, and as an antidote to magnesium intoxication due to overdosage of magnesium sulfate.	Protein S100-A13target
Chlorhexidine	An antiseptic used to sterilize for surgeries and in healthcare practice, to reduce pocket depth in periodontitis, and to treat gingivitis.	Bacterial outer membranetarget Albumincarrier
Dexpanthenol	An alcoholic analogue of D-pantothenic acid that is used as a supplement or application to support a healthy epithelium and is also used to prevent vitamin deficiency in patients receiving total parenteral nutrition (TPN).	No drug targets
Gluconic Acid	An electrolyte supplement used in total parenteral nutrition.	No drug targets
Glycine	An amino acid commonly used as a component of total parenteral nutrition and is also used as irrigation during surgery.	Glutathione synthetasetarget Glycine receptor subunit alpha-1target Alanine--glyoxylate aminotransferasetarget Glycine receptor subunit betatarget Serine hydroxymethyltransferase, cytosolictarget Glycine receptor subunit alpha-3target Glycine receptor subunit alpha-2target Glycine N-methyltransferasetarget Glycine amidinotransferase, mitochondrialtarget Glutamate receptor ionotropic, NMDA 3Btarget 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrialtarget 5-aminolevulinate synthase, non-specific, mitochondrialtarget 5-aminolevulinate synthase, erythroid-specific, mitochondrialtarget Glycine--tRNA ligasetarget Glutamate receptor ionotropic, NMDA 2Atarget Bile acid-CoA:amino acid N-acyltransferasetarget N-arachidonyl glycine receptortarget Glutamate receptor ionotropic, NMDA 2Ctarget Serine hydroxymethyltransferasetarget Glycine N-acyltransferasetarget Serine hydroxymethyltransferase, mitochondrialtarget Glycine N-acyltransferase-like protein 2target Glycine N-acyltransferase-like protein 1target Alanine--glyoxylate aminotransferase 2, mitochondrialtarget Peroxisomal sarcosine oxidasetarget Monocarboxylate transporter 10transporter Proton-coupled amino acid transporter 1transporter Vesicular inhibitory amino acid transportertransporter Sodium- and chloride-dependent glycine transporter 2transporter Sodium- and chloride-dependent glycine transporter 1transporter Aminomethyltransferase, mitochondrialenzyme Glycine dehydrogenase (decarboxylating), mitochondrialenzyme Dihydrolipoyl dehydrogenase, mitochondrialenzyme Glycine cleavage system H protein, mitochondrialenzyme
Magnesium chloride	An ionic compound and source of magnesium used for electrolyte replenishment and conditions associated with magnesium deficiencies.	No drug targets
Sodium acetate	A compound used for electrolyte replenishment and total parenteral nutrition (TPN) therapy.	Acetyl-coenzyme A synthetase, cytoplasmicenzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT05161780	Evaluation of Endoscopic Surgical Field Clarity Using Hot Saline Versus Lactated Ringer's Irrigation	Calcium chloride Lactic acid Potassium chloride Sodium chloride	treatment	1	recruiting