Urine alkalinization therapy (DBCOND0025145)

Identifiers

Synonyms

Alkaline urine / Alkalinizing agent / Alkalinizing Agents / Urine alkalinisation therapy / Antacid (substance) / Medicinal product acting as antacid agent (product) / Antacids

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Acetazolamide	A carbonic anhydrase inhibitor used to treat edema from heart failure or medications, certain types of epilepsy, and glaucoma.	Carbonic anhydrase 1target Aquaporin-1target Carbonic anhydrase 14target Solute carrier family 22 member 6transporter Carbonic anhydrase 2target Carbonic anhydrase 3target Carbonic anhydrase 4target Cytochrome P450 3A4enzyme Carbonic anhydrase 7target Carbonic anhydrase 12target
Calcium chloride	An ionic compound used for the treatment of hypocalcemia and hyperkalemia, and as an antidote to magnesium intoxication due to overdosage of magnesium sulfate.	Protein S100-A13target
Citric acid	An anti-chelation additive used in blood collection tubes and as a flavoring and preservative agent in various cosmetic and pharmaceutical products.	Beta-lactamase 2target Aldo-keto reductase family 1 member B1target Citrate synthase, mitochondrialtarget Proto-oncogene tyrosine-protein kinase Srctarget Ribonuclease pancreatictarget Isocitrate dehydrogenase [NADP]target Eosinophil cationic proteintarget Beta-lactamasetarget Fumarate hydratase class IItarget 6-phosphogluconolactonasetarget L-amino-acid oxidasetarget Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1target Cytochrome c peroxidasetarget Hepatocyte growth factor-regulated tyrosine kinase substratetarget Invasintarget Intron-associated endonuclease 1target Short tail fiber protein gp12target Malate dehydrogenase, mitochondrialtarget N5-carboxyaminoimidazole ribonucleotide mutasetarget 50S ribosomal protein L4target Carboxypeptidase Btarget Hexon proteintarget Riboflavin biosynthesis proteintarget Beta-fructosidasetarget Putative stringent starvation protein Atarget Citrate synthasetarget RNA 3'-terminal phosphate cyclasetarget U6 snRNA-associated Sm-like protein LSm6target Pleckstrin homology domain-containing family A member 1target Fe(3+)-binding periplasmic proteintarget Signal recognition particle receptor FtsYtarget Nicotinate-nucleotide adenylyltransferasetarget N utilization substance protein B homologtarget Complement component C8 gamma chaintarget Ribonucleoside-diphosphate reductase subunit betatarget Glutamine synthetase 1target 2-methylcitrate synthasetarget Prostaglandin F synthasetarget Adenine phosphoribosyltransferasetarget Glucose-1-phosphate thymidylyltransferasetarget Glyoxalase family proteintarget Laccase domain protein YfiHtarget Ribose-5-phosphate isomerase Atarget GMP synthase [glutamine-hydrolyzing]target Inosine triphosphate pyrophosphatasetarget Lysozymetarget Glycerol uptake operon antiterminator regulatory proteintarget 3-carboxy-cis,cis-muconate cycloisomerasetarget Pyruvate decarboxylasetarget Solute carrier organic anion transporter family member 2B1transporter Metallo-beta-lactamase type 2target Transient receptor potential cation channel subfamily V member 4target Lanosterol 14-alpha demethylasetarget
Dextrose, unspecified form	A form of glucose used for caloric supply and the replenishment of fluid in total parenteral nutrition and other therapies as well as for the treatment of hypoglycemic episodes.	Hexokinase-4enzyme Hexokinase-1enzyme Solute carrier family 2, facilitated glucose transporter member 1transporter Solute carrier family 2, facilitated glucose transporter member 2transporter Solute carrier family 2, facilitated glucose transporter member 3transporter Solute carrier family 2, facilitated glucose transporter member 4transporter Solute carrier family 2, facilitated glucose transporter member 6transporter Solute carrier family 2, facilitated glucose transporter member 7transporter Solute carrier family 2, facilitated glucose transporter member 8transporter Solute carrier family 2, facilitated glucose transporter member 9transporter Solute carrier family 2, facilitated glucose transporter member 10transporter Solute carrier family 2, facilitated glucose transporter member 11transporter Solute carrier family 2, facilitated glucose transporter member 12transporter Sodium/glucose cotransporter 1transporter
Dipotassium phosphate	An ionic compound used for electrolyte replenishment and total parenteral nutrition (TPN) therapy.	No drug targets
Gluconic Acid	An electrolyte supplement used in total parenteral nutrition.	No drug targets
Gluconic Acid	An electrolyte supplement used in total parenteral nutrition.	No drug targets
Lactic acid	An emollient and keratolytic used agent in various cosmetic products and used as an additive in various pharmaceutical products for its antibacterial properties.	Bifunctional protein PutAtarget NimA-related proteintarget Monocarboxylate transporter 2transporter Solute carrier organic anion transporter family member 2B1transporter Monocarboxylate transporter 1transporter Monocarboxylate transporter 10transporter Solute carrier organic anion transporter family member 2A1transporter Monocarboxylate transporter 4transporter
Magnesium acetate tetrahydrate	An ionic compound used for electrolyte replenishment and total parenteral nutrition (TPN) therapy.	Glutamate (NMDA) receptortarget
Magnesium chloride	An ionic compound and source of magnesium used for electrolyte replenishment and conditions associated with magnesium deficiencies.	No drug targets
Potassium chloride	A potassium salt used to treat hypokalemia.	Solute carrier family 12 member 2target Solute carrier family 12 member 1target Solute carrier family 12 member 5target Solute carrier family 12 member 6target Solute carrier family 12 member 7target Solute carrier family 12 member 4target Solute carrier family 12 member 2transporter Solute carrier family 12 member 1transporter Solute carrier family 12 member 5transporter Solute carrier family 12 member 6transporter Solute carrier family 12 member 7transporter Solute carrier family 12 member 4transporter
Sodium chloride	An ingredient found in a variety of nutritional products as a source of electrolytes and water.	No drug targets
Sodium citrate	An ingredient used for the anticoagulation of whole blood as part of automated apheresis procedures.	Mitochondrial 2-oxodicarboxylate carriertransporter Solute carrier family 13 member 2transporter Na(+)/citrate cotransportertransporter Tricarboxylate transport protein, mitochondrialtransporter Carbonic anhydrase 4target

Clinical Trials

Not Available